Antigen-binding molecule comprising TNF family ligand trimer

摘要

The present invention includes (a) at least one portion having a specific binding ability to a target cell antigen and (b) first and second polypeptides that are bound to each other by a disulfide bond, wherein the first polypeptide is a peptide linker. Characterized in that it comprises two ectodomains of a TNF ligand family member or a fragment thereof that are connected to each other by the method, and a second polypeptide comprises only one ectodomain of the TNF ligand family member or a fragment thereof, Of TNF family ligand trimer-containing antigen-binding molecules. [Selection figure] None