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ANTIGEN-BINDING MOLECULES CONTAINING TRIMER LIGAND OF TNF FAMILY AND PD1-BINDING Fragment
ANTIGEN-BINDING MOLECULES CONTAINING TRIMER LIGAND OF TNF FAMILY AND PD1-BINDING Fragment
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机译:包含TNF家族三聚体配体的抗原结合分子和PD1结合片段
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摘要
The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to PD1 and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.
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