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Designer cells for enantioselective reduction of ketones and their use in efficient production of enantioenriched alcohols
Designer cells for enantioselective reduction of ketones and their use in efficient production of enantioenriched alcohols
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机译:用于对映体选择性还原酮的设计器单元及其在高效生产对映体富集的醇中的用途
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摘要
The present invention is to provide a preparation of variant recombinant whole cell biocatalysts, referred herein as “designer cells” having significantly enhanced carbonyl reductase activity for use in the efficient production of variant industrially important enantiomerically enriched alcohols. More specifically, the alcohol is optically pure ethyl (S)-4-chloro-3-hydroxybutyrate, which is useful as chiral building block and an intermediate for the production of hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors.
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