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Lantibiotics MU1140 and other lantibiotic variants with improved pharmacological and structural characteristics
Lantibiotics MU1140 and other lantibiotic variants with improved pharmacological and structural characteristics
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机译:羊毛硫菌素MU1140和其他具有改进的药理和结构特性的羊毛硫菌素变体
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摘要
The invention provides improvements of lantibiotics useful for reducing the numbers of microbes or the reproduction of microbes in or on subjects or objects. One embodiment of the invention provides variants of MU1140 wherein the amino acid at position (1) is changed to Gly, the amino acid at position (4) is changed to an Ala, or the amino acid at position (13) is substituted with Asp, or combinations of two or more these changes or a pharmaceutically acceptable salt thereof.
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