Genetic testing to predict resistance of Klebsiella species to antibacterial agents

摘要

The present invention is parC, KPN01607, gyrA, KPN02451, baeR, aceF, ybgH, ynjE, KPN01951, KPN01961, KPN02114, mhpA, KPN02128, KPN02144, KPN02149, ydiJ, btuE02, thp02, thK02 ftn, cbl, hisB, yegQ, yehY, KPN02580, yejH, KPN02621, yfaW, KPN02170, KPN02025, livG, livM, libH, fliY, yedQ, aggB, treA, baeS, KPN02399, Kc02399, yC KPN01752 and KPN04195, side by side A method for determining infection of a patient with a Klebsiella species that is potentially resistant to antimicrobial treatment by detecting mutations in the genes of KOX26125, KOX13365, KOX16735, KOX25695, KOX12270, and KOX15055; It relates to a method for selecting treatment of a patient suffering from an infection; and a method for determining an antibiotic resistance profile of bacterial microorganisms of Klebsiella species, and a computer program product used in these methods. In an exemplary method, the sample is used for molecular testing and then molecular fingerprinting is performed. The results are then compared with a reference library and the results are reported.