System and method for evaluating modulators of immune checkpoints

摘要

Provided herein are compositions, systems, and methods for assessing modulators of immune checkpoints. In particular, artificial antigen-presenting cells (aAPC) and immune effector cells for assessing the efficacy of test factors that inhibit immune checkpoints are provided. In some embodiments, the composition comprises an artificial antigen presenting cell (aAPC) or phospholipid droplet presenting (1) an antigen response element activator and (2) an immune checkpoint ligand (ICL) on the surface. Provided in the specification. In some embodiments, the antigen response element activator is a T cell receptor (TCR) complex activator. [Selection] Figure 1