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Materials and methods for diagnosis of pancreatic ductal carcinoma, prognosis, monitoring of recurrence and evaluation of therapeutic / prophylactic treatment
Materials and methods for diagnosis of pancreatic ductal carcinoma, prognosis, monitoring of recurrence and evaluation of therapeutic / prophylactic treatment
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机译:诊断胰腺导管癌的材料和方法,预后,复发监测以及治疗/预防性治疗的评估
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摘要
A method of detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract or inferring an increased risk thereof, comprising obtaining a sample of pancreatobiliary cells from a patient with a set of detectably labeled probes comprising a locus-specific probe for MCL1 (myeloid cell leukemia sequence 1), a locus-specific probe for EGFR (epidermal growth factor receptor), a locus-specific probe for MYC, and a locus-specific probe for P16 under hybridization conditions and determining the presence of chromosomal abnormalities; a set of probes comprising a locus-specific probe for MCL1, a locus-specific probe for EGFR, a locus-specific probe for MYC, and a locus-specific probe for P16; and a kit comprising the set of probes and instructions for detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract, or inferring an increased risk thereof, in a patient.
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