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Regulation of apolipoprotein C-III (APOCIII) expression in a lipoprotein lipase deficient (LPLD) population
Regulation of apolipoprotein C-III (APOCIII) expression in a lipoprotein lipase deficient (LPLD) population
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机译:脂蛋白脂肪酶缺乏症(LPLD)人群中载脂蛋白C-III(APOCIII)表达的调节
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摘要
Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in a patient with Fredrickson Type I dyslipidemia, FCS, LPLD. Also provided herein are methods, compounds, and compositions for treating, preventing, delaying, or ameliorating Fredrickson Type I dyslipidemia, FCS, LPLD, in a patient. Further provided herein are methods, compounds, and compositions for increasing HDL levels and/or improving the ratio of TG to HDL and reducing plasma lipids and plasma glucose in a patient with Fredrickson Type I dyslipidemia, FCS, LPLD. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of pancreatitis, cardiovascular disease or metabolic disorder, or a symptom thereof.
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