2- (1H-Indol-4-ylmethyl) -3H-imidazo 4,5-b pyridine-6-carbonitrile derivatives as complement factor B inhibitors useful for the treatment of ophthalmic diseases

摘要

The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as Factor B inhibitors for the treatment of conditions and diseases associated with complement alternative pathway activation such as age-related macular degeneration, diabetic retinopathy and related ophthalmic diseases. The present invention further provides pharmaceutical compositions and combinations of pharmacologically active agents.