Methods, apparatus and articles of manufacture are disclosed to manage inter-virtual disk relations in a modularized virtualization topology using virtual hard disks. An example method includes, in response to a request to access a first virtual hard disk in a virtual computing environment, determining, with a machine, whether an inter-virtual hard disk rule associated with a second virtual hard disk is invoked and whether a condition of the inter-virtual hard disk rule is satisfied. The example method also includes identifying, with the machine, a response action if the inter-virtual hard disk rule is invoked and the condition is satisfied, and executing the response action with the machine.
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