Undertaking a wellbore operation while monitoring wellbore pressure with stationary pressure sensors coupled to tubing extended within the wellbore and thereby generating downhole annulus signals in real-time. The wellbore pressure is also monitored at or near a surface location during the wellbore operation with surface pressure sensors that generate a measured wellhead pressure. The downhole annulus pressure signals are received at an outer loop controller that provides a desired wellhead pressure based on a difference between the real-time downhole annulus pressure signals and a desired pressure setpoint. The measured and desired wellhead pressures are received with an inner loop controller that provides command signals based on a difference between the measured and desired wellhead pressures. The command signals are received by flow control devices that adjust a backpressure within the wellbore based on the command signals.
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