METHODS TO PREVENT TISSUE COLONIZATION OF PATHOGENS AND FOR TREATMENT OF BIOFILM ON ANIMAL TISSUES, INCLUDING TREATMENT OF INFECTION

摘要

An antimicrobial product and methods of use are provided. The antimicrobial product includes a water-soluble antimicrobial organosilane (3-(trihydroxysilyl) propyldimethyloctadecyl ammonium chloride) and various additional adjuvant compounds, including anti-inflammatory medications, antiseptics, penetrants and/or detergents. An example delivery system including a microcapsule encasing the product is also described. Methods of use include embedding a delivery system within an article, such as bandages, inserts or wound coverings, the microcapsule containing the product which is released by a mechanism and at a time particular to the intended use of the article. The methods include topically treating a biofilm infection on an animal tissue substrate by disrupting existing microbial biofilm growth, penetrating existing biofilms, thereby killing microbes, and also through providing residual bonded organosilane, then killing persister cell microbes that through degrees of dormancy have escaped being killed.