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Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
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机译:使用具有毫秒级时间分辨率的基于阻抗的系统,无标记地监测激励-收缩耦合和可激励单元
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摘要
A system for monitoring impedance of excitable cells in vitro, which includes a device for monitoring cell-substrate impedance at 20 millisecond resolution, which includes a nonconductive substrate with one or more electrode arrays fabricated in one or more wells, wherein cell attachment on the substrate can result in a detectable change in impedance between electrodes within each electrode array; an impedance analyzer capable of impedance measurement at 20 millisecond time resolution; electronic circuitry that can engage said device and selectively connect said two or more electrode arrays of said device to said impedance analyzer; and a software program that controls said electronic circuitry and records and analyzes data obtained from said impedance analyzer.
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