The present disclosure provides a radiofrequency genicular nerve denervation probe and methods of using the probe to address chronic knee pain by producing therapeutic lesions or tissue alterations. In many embodiments, the denervation probe is a steerable, multi-electrode probe that includes one or more injection ports that allow one or more fluids to be injected at the target site before, during, or after a denervation procedure. The denervation probe may also include in many embodiments one or more thermocouples configured to provide targeted temperature readings. The denervation probe has the capability to perform a customized or preset sequence of lesions to provide desirable procedural flexibility.
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