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Chemically ligated RNAs for CRISPR/Cas9-lgRNA complexes as antiviral therapeutic agents
Chemically ligated RNAs for CRISPR/Cas9-lgRNA complexes as antiviral therapeutic agents
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机译:用于CRISPR / Cas9-lgRNA复合物的化学连接RNAs作为抗病毒治疗剂
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摘要
Provided herein are chemically ligated guide RNA oligonucleotides (lgRNA) which comprise two functional RNA modules (crgRNA and tracrgRNA) joined by non-nucleotide chemical linkers (nNt-linker), their complexes with CRISPR-Cas9, preparation methods of Cas9-lgRNA complexes, and their uses for treatments of viral infections in humans. Also disclosed are processes and methods for preparation of these compounds.
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