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INHIBITORS OF MIR-17-92 CLUSTER FOR ANTI-TUMOR ACTIVITY IN MULTIPLE MYELOMA AND OTHER MALIGNANCIES
INHIBITORS OF MIR-17-92 CLUSTER FOR ANTI-TUMOR ACTIVITY IN MULTIPLE MYELOMA AND OTHER MALIGNANCIES
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机译:MIR-17-92抑制剂在多发性骨髓瘤和其他恶性肿瘤中的抗肿瘤活性
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摘要
The present invention refers to inhibitors of the miR-17-92 cluster and to their use as medicaments, in particular in the treatment of multiple myeloma and other malignancies. More in particular, the present invention refers to an LNA/DNA gapmer which binds to a region of the primary miRNA (pri-miRNA) of the miR-17-92 cluster Said inhibitors can be used for the treatment of tumors related to an overexpression of any of the miRNAs of the miR-17-92 cluster. Pharmaceutical compositions are also within the scope of the invention.
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