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Intravascular magnetic wire for detection, retrieval or elimination of disease-associated biomarkers and toxins
Intravascular magnetic wire for detection, retrieval or elimination of disease-associated biomarkers and toxins
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机译:用于检测,检索或消除与疾病相关的生物标记和毒素的血管内电磁线
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摘要
A medical device and method for detection, retrieval or elimination of disease-associated toxins and biomarkers is provided. A plurality of magnets is arranged within a flexible sheath forming a flexible wire. The magnets are magnetically attached to each other, end-to-end, and arranged with their magnetic polarities alternating in direction. The magnetization direction of each of the magnets is orthogonal to the length axis of the flexible wire. The medical device is completely self-contained and does not require a bulky external field source able to maintain strong magnetic field gradients (100-10,000 T/m) along the wire, and at a radial distance (˜1 mm) to attract magnetic particles throughout the entire vein diameter at a range of physiologic velocities (1-10 cm/sec). This technology is a major step forward for the clinical relevance of CTC analysis to personalized medicine and introduces a powerful generalizable strategy for enrichment of other rare blood biomarkers.
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机译:提供了一种用于检测,检索或消除与疾病相关的毒素和生物标志物的医疗设备和方法。多个磁体布置在柔性护套内,从而形成柔性线。磁体首尾相连地彼此磁性附接,并且其磁极性在方向上交替布置。每个磁体的磁化方向与柔性线的长度轴正交。该医疗设备是完全独立的,不需要庞大的外部场源,该外部场源能够沿导线并沿径向距离(〜1 mm)保持强磁场梯度(100-10,000 T / m)以吸引磁性颗粒在一定的生理速度范围内(1-10厘米/秒)在整个静脉直径上分布。这项技术是CTC分析与个性化医学在临床上相关性迈出的重要一步,并为丰富其他稀有血液生物标记物引入了强大的通用策略。
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