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METHODS FOR IMPROVING CRISPR/CAS-MEDIATED GENOME-EDITING
METHODS FOR IMPROVING CRISPR/CAS-MEDIATED GENOME-EDITING
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机译:改善CRISPR / CAS介导的基因组编辑的方法
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摘要
This application provides improved methods of editing the genome of a target cell. Cas9 molecules can be used to create a break in a genomic region of interest. To increase the likelihood that the break is repaired by homology-directed repair (HDR), the cell can be contacted with an HDR-enhancer. The cell may be, e.g., a human cell, a non-human animal cell, a bacterial cell, or a plant cell.
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