METHODS FOR COMPARING A STRUCTURE OF A FIRST BIOMOLECULE AND A SECOND BIOMOLECULE

摘要

The present disclosure provides methods to assess structural similarity of a first biomolecule and a second biomolecule by detecting one or more responses of the first and second biomolecule to thermodynamic stress conditions induced by osmotic and dielectric changes including, detecting a shift in fluorescence emission and/or a change in the intensity of the emission.