COMPOSITIONS AND METHODS FOR CREATING PANCREATIC CANCER ANIMAL MODEL

摘要

Certain embodiments are directed kits comprising components for producing a mammalian cancer model. In certain aspects the components are expression vectors. In certain embodiments one or more expression vector is engineered to express a Kras^G12D polypeptide, a p53 transcriptional suppressor, SMAD4 transcriptional suppressor, p16/CDKN2A transcriptional suppressor. In certain aspects the transcriptional suppressor is a short hairpin RNA (shRNA) or other nucleic acid used for RNA interference.