METHODS, MEANS AND COMPOSITIONS FOR IMPROVING OUTCOMES OF SURGICAL INTERVENTIONS AND INFLAMMATORY SEQUEL

摘要

Disclosed are methods, means and compositions of matter useful for improving outcomes after surgical interventions, said improvements including reduction of pain, acceleration of healing, reduction of fibrosis, inflammation and formation of surgical adhesions. Said surgical interventions include manipulation of tissues by means of mechanical, surgical, and ablative means. Said compositions include noble gases which directly or indirectly induce antifibrotic, anti-inflammatory and pain ameliorating effects. Said gases are injected directly during the procedure of tissue manipulation, or contacted with fluids, or fluids containing cells that are subsequently injected adjacent to said tissue being manipulated. In one embodiment of the invention, laparoscopic surgery is performed using noble gases to insufflate the said body cavities. In another embodiment, said noble gases are used to treat liquids added during said manipulations of tissue, including surgical manipulation. In a specific embodiment, the invention teaches the use of xenon gas to enhance outcomes subsequent to surgical manipulation.