COMPOUNDS FOR USE AS THERAPEUTIC AGENTS AFFECTING P53 EXPRESSION AND/OR ACTIVITY

摘要

The present disclosure relates to compound (I); ;wherein R1 and R2 independently represent a hydrogen atom, a (C₁-C₄)alkoxy group, a fluoro(C₁-C₄)alkoxy group, a hydroxyl group, a benzyloxy group, a di(C₁-C₄)alkylamino group, a pyridyl-vinyl group, a pyrimidinyl-vinyl group, a styryl group, or a —NHCOphenyl group; R3, R4 and R5 independently represent a hydrogen atom, a (C₁-C₄)alkyl group, a CONHR6 group, a —CONR7R8 group, a —SO₂NHR6 group, or a heteroaryl group optionally substituted by a halogen atom, a —(CH₂)_nNR7R8 group or a hydroxy(C₁-C₄)alkyl group; R6 represents a hydrogen atom, a —(CHR9)_m(CH₂)_nNR7R8 group or a (C₁-C₆)alkyl group optionally substituted by a hydroxyl group; or anyone of its pharmaceutically acceptable salt, for use in a method for preventing, inhibiting or treating a disease in a patient suffering thereof, said disease involving a deregulated p53. Some of said compounds are new and also form part of the disclosure.