首页> 外国专利> METHOD FOR INCRESING EXPRESSION OF PTPRD GENE BY USING PEANUT SKIN EXTRACT

METHOD FOR INCRESING EXPRESSION OF PTPRD GENE BY USING PEANUT SKIN EXTRACT

机译：花生皮提取物提高PTPRD基因表达的方法

页面导航

摘要
著录项
相似文献

摘要

A method for increasing the expression of PTPRD gene is provided, wherein the method comprises administering to a subject in need an effective amount of a peanut skin extract. The method is effective in preventing or treating diseases related to PTPRD gene.

机译：提供了一种增加PTPRD基因表达的方法，其中该方法包括向需要的受试者施用有效量的花生皮提取物。该方法有效预防或治疗与PTPRD基因有关的疾病。

著录项

公开/公告号US2018303893A1

专利类型
公开/公告日2018-10-25

原文格式PDF
申请/专利权人 TCI CO. LTD.;
展开▼

申请/专利号US201815957630
发明设计人 YUNG-HSIANG LIN;CHIH-HSIU YU;
展开▼

申请日2018-04-19
分类号A61K36/48;
国家 US
入库时间 2022-08-21 13:00:43

相似文献

专利
外文文献
中文文献

1. Influence of peanut skin extract on shelf-life of sheep patties [J] . Mariza Pires de Melo, Marco Antonio Trindade, Jose Manuel Lorenzo 亚太热带生物医学杂志（英文版） . 2016,第007期

2. Influence of peanut skin extract on shelf-life of sheep patties [J] . Paulo Eduardo Sichetti Munekata, Rafaella de Paula Paseto Fernandes, Mariza Pires de Melo, 亚太热带生物医学杂志：英文版 . 2016,第007期

3. In vitro effects of peanut skin polyphenolic extract on oxidative stress, adipogenesis, and lipid accumulation [J] . Annayara C. F. Fernandes, Adina L. Santana, Natalia C. Vieira, Journal of Food Processing and Preservation . 2021,第10期

4. Study of physicochemical stability of anthocyanin extracts from black peanut skin and their digestion enzyme and adipogenesis inhibitory activities [J] . Peng Jinming, Jia Yan, Du Xia, LWT-Food Science & Technology . 2019,第期

5. Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse [J] . Siddens Lisbeth K., Bunde Kristi L., Harper Tod A., Toxicology and Applied Pharmacology . 2015,第2期

6. Isolating Peanut Pod Shell Specific Expression Genes by SSH and DD-mRNA Methods [C] . W.J.Zhuang, N.B.Cai, Z.Y.Li, 第二届植物分子育种国际会议论文集 . 2007

7. Development of a Peanut-Sweetpotato Ready to Use Therapeutic Food and Evaluation of Peanut Skins in Peanut Products. [D] . Hathorn, Chellani S. 2013

8. RNAi-mediated Control of Aflatoxins in Peanut: Method to Analyze Mycotoxin Production and Transgene Expression in the Peanut/Aspergillus Pathosystem [O] . Renée S. Arias, Phat M. Dang, Victor S. Sobolev 2015

9. Extracts of Peanut Skins as a Source of Bioactive Compounds: Methodology and Applications [O] . Lisa L. Dean 2020

1. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004）（P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期

2. Gene Expression:A Review on Methods for the Study of Defense-Related Gene Differential Expression in Plants [J] . Alice Casassola ,Sandra Patussi Brammer ,Márcia Soares Chaves . 美国植物学期刊（英文） . 2013,第12期

3. Antioxidant and Anti-Inflammatory Effects of Peanut Skin Extracts [J] . Wanida E. Lewis ,Gabriel K. Harris ,Timothy H. Sanders . 食品与营养科学（英文） . 2013,第8期

4. 提高薄壁滚花件原材料利用率方法研究 [C] . 孙颜利 ,彭凤兰 ,徐继斌 . 2012兵工企业数字化技术发展学术研讨会 . 2012

5. 提高腺病毒和腺相关病毒载体介导外源基因表达的方法及机理研究 [A] . 张圣海 . 2007