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ANTAGONISTS FOR INTERLEUKIN-17 RECEPTOR B (IL-17RB) AND ITS LIGAND IL-17B FOR CANCER THERAPY

机译：白介素17受体B（IL-17RB）及其配体IL-17B的抗癌药

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摘要

Methods and compositions for treatment and therapy of cancer are provided. Specifically, antagonists specific for interleukin-17 receptor B (IL-17RB) and its ligand IL-17B are provided. Potent neutralizing antibodies specific for IL-17RB and methods for their manufacture and use are disclosed. The invention also relates to antisense, RNAi and shRNA compositions for the prevention and treatment of cancer, in particular breast cancer and pancreatic cancer.

机译：提供了用于治疗和治疗癌症的方法和组合物。具体而言，提供了对白介素17受体B（IL-17RB）及其配体IL-17B具有特异性的拮抗剂。公开了对IL-17RB特异的有效中和抗体及其制造和使用方法。本发明还涉及用于预防和治疗癌症，特别是乳腺癌和胰腺癌的反义RNAi和shRNA组合物。

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公开/公告号US2018201672A1

专利类型
公开/公告日2018-07-19

原文格式PDF
申请/专利权人 WEN-HWA LEE;ACADEMIA SINICA;
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申请/专利号US201515322788
发明设计人 WEN-HWA LEE;JIN-YUH SHEW;CHE MA;CHIA-LIN CHEN;WEN-HSIN LEE;CHUN-KAI HUANG;HENG-HSIUNG WU;
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申请日2015-06-30
分类号C07K16/24;A61P35;C12N15/113;A61K39/395;A61K45/06;C07K14/715;
国家 US
入库时间 2022-08-21 13:00:37

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