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SINGLE CHAIN ANTIBODY DOMAINS FOR DETECTION OF ANTI-BOTULINUM NEUROTOXIN DOMAINS AND METHODS OF THEIR USE
SINGLE CHAIN ANTIBODY DOMAINS FOR DETECTION OF ANTI-BOTULINUM NEUROTOXIN DOMAINS AND METHODS OF THEIR USE
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机译:用于检测抗肉毒杆菌神经毒素域的单链抗体域及其使用方法
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摘要
Provided herein, inter alia, are single chain antibody binding domains (VHHs) for use in conjunction with the Assay with a Large Immuno-sorbent Surface Area (ALISSA). Engineered and affinity matured VHHs are used as affinity reagents in the ALISSA resulting in an exceptionally sensitive and precise method for the detection of toxins at miniscule concentrations. Thus, provided herein are methods as well as reagents that can be used to detect the presence of botulinum neurotoxins in quantities well below 1 pg/mL which corresponds to a lethal concentration under presumed equal distribution throughout the human body.
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