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MONOCLONAL ANTIBODIES SPECIFIC FOR SEROGROUP X OF N. MENINGITIDIS AND USES THEREOF IN DIAGNOSIS
MONOCLONAL ANTIBODIES SPECIFIC FOR SEROGROUP X OF N. MENINGITIDIS AND USES THEREOF IN DIAGNOSIS
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机译:脑膜炎奈瑟氏菌血清群X特异的单克隆抗体及其在诊断中的应用
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摘要
The present invention is directed to monoclonal antibodies and antigen-binding portions thereof, specific for the capsular polysaccharides of Neisseria meningitidis serogroup X (NmX), wherein said antibodies or portions thereof are characterized by the sequences of the 6 CDR of the variable regions of the heavy and light chains. These antibodies are suitable for in vitro detection of Neisseria meningitidis serogroup X especially in a biological sample without purification of the capsular polysaccharides. The invention also concerns said monoclonal antibodiesor adequate portions thereofin different diagnostic tests and methods, in order to detect NmX. The invention discloses also a rapid diagnostic test for detecting NmX in a biological fluid.
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