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High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs
High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs
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机译:高滴度重组流感病毒,在MDCK或vero细胞或卵中复制增强
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摘要
The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza virus vaccine strain or isolate, e.g., one that is safe in humans, for instance, one that does not result in significant disease, that confer enhanced growth in cells in culture, such as MDCK cells, or in eggs.
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