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LONG TERM HEMATOPOIETIC STEM CELL SPECIFIC REPORTER MOUSE AND USES THEREOF

机译:长期造血干细胞特异性报告基因小鼠及其用途

摘要

Hoxb5 identifies long-term hematopoietic stem cells. Expression of Hoxb5 distinguishes between LT-HSCs and non-LT-HSCs, and the marker identifies substantially all LT-HSC in the bone marrow. By utilizing fluorescent proteins under the endogenous expression control of Hoxb5, LT-HSC can be monitored and isolated, including without limitation detection and monitoring of HSC in bone morrow; production of LT-HSC from pluripotent stem cells such as iPS cells; for analysis of early stage LT-HSC; in screening methods for expansion and manipulation of LT-HSC, and the like.
机译:Hoxb5可以识别长期造血干细胞。 Hoxb5的表达可区分LT-HSC和非LT-HSC,并且标记物可识别骨髓中基本上所有的LT-HSC。通过在Hoxb5的内源性表达控制下利用荧光蛋白,可以监测和分离LT-HSC,包括但不限于在骨骼中检测和监测HSC。从多能干细胞(如iPS细胞)生产LT-HSC;用于分析早期LT-HSC;用于LT-HSC的扩增和操作的筛选方法等。

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