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LONG TERM HEMATOPOIETIC STEM CELL SPECIFIC REPORTER MOUSE AND USES THEREOF
LONG TERM HEMATOPOIETIC STEM CELL SPECIFIC REPORTER MOUSE AND USES THEREOF
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机译:长期造血干细胞特异性报告基因小鼠及其用途
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摘要
Hoxb5 identifies long-term hematopoietic stem cells. Expression of Hoxb5 distinguishes between LT-HSCs and non-LT-HSCs, and the marker identifies substantially all LT-HSC in the bone marrow. By utilizing fluorescent proteins under the endogenous expression control of Hoxb5, LT-HSC can be monitored and isolated, including without limitation detection and monitoring of HSC in bone morrow; production of LT-HSC from pluripotent stem cells such as iPS cells; for analysis of early stage LT-HSC; in screening methods for expansion and manipulation of LT-HSC, and the like.
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