T CELL DELIVERY OF MDA-7/IL-24 TO IMPROVE THERAPEUTIC ERADICATION OF CANCER AND GENERATE PROTECTIVE ANTITUMOR IMMUNITY

摘要

Provided herein are methods and compositions useful for treating cancer, such as prostate cancer, through adoptive cell transfer of T cells derived from patients and genetically engineered to express MDA-7/IL-24 and/or other immune modulating agents. The methods described herein result in cancer cell death and reprogramming of the tumor immune compartment to restore antitumor immunity both at a primary tumor site and systemically.