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Time Lapse Sequencing: A convertible-nucleoside approach to enrichment-free analysis of RNA dynamics
Time Lapse Sequencing: A convertible-nucleoside approach to enrichment-free analysis of RNA dynamics
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机译:延时测序:可转换的核苷方法,可对RNA动力学进行无浓缩分析
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摘要
The invention provides methods and compositions for generating mutations in new nucleic acid molecules through incorporation of a transformable nucleoside into the nucleic acid and subsequent transformation of the nucleoside through oxidative-nucleophilic-aromatic-substitution chemistry, referred to as TimeLapse chemistry. The invention further provides methods for detecting the mutations, referred to as TimeLapse-seq.
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