A system for training a cirrhosis forecast model includes a computing platform having a hardware processor and a memory storing a software code for training the cirrhosis forecast model. The hardware processor executes the software code to receive medical data for each of multiple human subjects, assign a subset of the human subjects as a training group for the cirrhosis forecast model, and identify cirrhosis predictive parameters from the medical data for the training group. The hardware processor also executes the software code to generate a cirrhosis forecast model including a weighted combination of the cirrhosis predictive parameters, produce, using the cirrhosis forecast model, a cirrhosis prediction for at least one of the human subjects omitted from the training group, determine an accuracy of the cirrhosis prediction, and adapt the cirrhosis forecast model based on the accuracy of the cirrhosis prediction.
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