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Energy-providing bone-repair degradable porous scaffold, preparation method thereof, and application thereof

机译:提供能量的骨修复降解多孔支架及其制备方法和应用

摘要

The invention discloses an energy-providing bone-repair degradable porous scaffold, a preparation method thereof, and an application thereof. The invention obtains an energy-based biomaterial solution by compositing gelatin, a polyatomic acid and derivatives thereof, a dibasic alcohol and derivatives thereof, and a tribasic alcohol and derivatives thereof in a chemical cross-linking manner by using diisocyanate, and further obtains a porous scaffold through a drying method. The porous scaffold can avoid the problem of an acidic microenvironment caused by in vivo implantation of the existing biomaterial and keep the activity of an osteoblast cell, thereby improving the rate of repairing the damaged bone tissue with the energy-based biomaterial. The porous scaffold of the invention can be used as a filling material for bone repair in a surgical operation.
机译:本发明公开了一种能供能量的骨修复降解多孔支架及其制备方法和应用。本发明通过使用二异氰酸酯以化学交联的方式混合明胶,多原子酸及其衍生物,二元醇及其衍生物,以及三元醇及其衍生物来获得基于能量的生物材料溶液,并进一步获得了多孔材料。脚手架通过干燥方法。该多孔支架可以避免因现有生物材料的体内植入而引起的酸性微环境问题,并保持成骨细胞的活性,从而提高了基于能量的生物材料修复受损骨组织的速率。本发明的多孔支架可用作外科手术中骨修复的填充材料。

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