Nutritional compositions for the Promotion of the function of intestinal barrier and visceral Pain Relief

摘要

Methods to promote intestinal Regeneration, (ii) Promoting the adaptation and / or intestinal maturation.(iii) support the Resistance of the intestinal barrier and / or (iv) protect the intestinal Barrier function in a subject comprising administering to the subject a Paediatric Paediatric composition CompRende, an effective amount of a preparation of a soluble Mediator derived from late Exponential growth phase of a probiotic Culture Process batchSuch as Lactobacillus rhamnosus GG (LGG).The Method of claim claim 7: 2Where the preparation of a soluble Mediator is produced by subjecting (LGG) cultured in a suitable Culture Medium using a batch process; (b) to collect the Culture supernatant in aTo late Exponential growth phase of a step cultivationWhose phase is defined with reference to the second half of the time delay between the phase and The Stationary phase of batch cultivation process; (c) optionally remove constituents of low PThe supernatant so that molecular constituents of retain Molecular Weight of over 5 or 6 kDa; (d) to eliminate any remaining cells through sterile Filtration of 0.2 mm to provide for the preparation of soluble Mediator; (e) to withdraw The Liquid content of the preparation of soluble Mediator so as to obtain the composition.Claim 13: Method of claim 2, wherein the composition is a Pediatric Nutritional composition.A formula for 15 Claims: (i) to promote the regeneration of the intestinal Barrier, (ii) Promote maturation of intestinal Barrier,(iii) support the Resistance of the intestinal barrier and / or (iv) protect the function of intestinal Barrier in a Baby that includes: until around 7 g / 100 kcal of Fat or Lipid until around;R 5 g / 100 kcal a Protein Source or an equivalent source of Protein; until about 22 g / 100 kcal a carbohydrate Source; and preparation of a soluble Mediator from aA late Exponential growth phase of batch cultivation process of Lactobacillus rhamnosus GG (LGG).The Composition of the 19 Claims: claim 14, which also comprises lactoferrin.