GPR119 agonists compounds and Method for treating diseases and conditions mediated through GPR119

摘要

The formula compound (1) referred to in this document is the promoter of gpr119, the compound containing these compounds and the preparation method thereof. 1. Requirement 1: a compound (1) with formula characteristics,There, x1,X2,X³ and X⁴ are each independently N, O, S, or CH; Y is selected from H, OH, halogen, C₁₋₆ alkyl, C₁₋₆ alkoxy, - (CH) ₙ,Amino, Co, CONH, NH (TAR)-N (rental) 832222,-NH-aralquilo -OCH (CH)N is 0, 1, 2 or 3;; 8315; - 8315; - 8315; - 8315; - 8315; - 8315; - independent of single or double bond, provided that the adjacent double bond (= C =) is not allowed to be used; R 1 is selected from the legacy of formula group (2);R2 was selected from the residue of formula group (3);R³ is selected from H, OH, halogen, C₁₋₆-alkyl,C₁₋₆ alkoxy,- (CH)Amino, Co, CONH, NH (TAR)-N (rental) 832222,-NH-aralkyl, -CF₃,-OCH (CH)A month agoa. Other formula (5);And acceptable salts, hydrates and stereoisomers of drugs.