GPR119 agonists compounds and Method for treating diseases and conditions mediated through GPR119

摘要

1.3.4 - endosulfan derivative, its preparation process and composition of these compounds. 1. Requirement 1: a compound (1) with formula characteristics,There, x1,X2,X3,X⁴ and X⁵ are each independently N, O, S, or CH; and X⁴ and X⁵ may optionally be combined to form a five-membered ring comprising one or more heteroatoms each independently selected from N, O, and S and the additional five-membered ring may further be optionally substituted with one or more of the group selected from F, Cl, Br, I, CF₃ and C₁₋₆ alkyl; R¹ and R² is independently selected from the group consisting of -H, -O, C₁₋₆ alkyl, C₁₋₆ alkoxy, - (CH₂) ₙ,Amino, Co, CONH, NH (TAR)-N (rental) 832222,-NH-aralquilo -CH O -OCH (CH)Halogen, synergistic,-CONR³R⁴,NR³COR⁴;R³ and R⁴ is independently selected from the group consisting of hydrogen or C₁₋₆ straight chain or branched chain alkyl which may be further substituted by halogen or C₁₋₆ alkyl; n is 0, 1, 2, or 3; A is selected from the residues of the group of formulas (2);B. select (3) from the remains of formula group;And acceptable salts, hydrates and stereoisomers of drugs.