Pirazolopirimidina derivatives

摘要

1. Requirement 1: a compound (1) with common formula characteristics,a. 0, 1, 2, 3, or 4; R from hydrogen, halogen, cyanogen, nitrogen-oh, c83321; bicycle, nh832222,-NH (C -alquilo)-N (C -alquilo)-S-C₁₋₄-alkyl, -S (O) -C₁₋₄-alkyl, -SO₂-C₁₋₄-alkyl, -S-C₁₋₄-halogenoalkyl, -S (O) -C₁₋₄-halogenoalkyl and -SO₂-C₁₋₄-halogenoalkyl having 1 to 5 halogen atoms; n is 0 or 1; X, Y are independently selected from the group consisting of CR⁵R⁶,O. S, and n-r8311;where at least one of X and Y is CR⁵R⁶;R¹ is selected from the group consisting of hydrogen, -CHO, -OH, C₁₋₄-alkyl, C₁₋₄-haloalkyl having 1 to 5 halogen atoms, C₁₋₄-alkoxy, C₁₋₄-haloalkoxy which it has between 1 and 5 halogen atoms, C₃₋₆-cycloalkyl, C₃₋₆-halogenocycloalkyl having between 1 and 5 halogen atoms, C₃₋₄-alkenyl, C₃₋₄-alkynyl, C₁₋₄-alkoxy-C₁₋ ₄-alkyl, C₃₋₆-cycloalkyl-C₁₋₃-alkyl, cyano-C₁₋₄-alkyl, amino-C₁₋₄-alkyl, C₁₋₄-alkylamino-C₁₋₄-alkyl, di- (C₁₋₄ -alkyl) amino-C₁₋₄-alkyl, C₁₋₄-alkylcarbonyl,C₁₋₄-halogenalkylcarbonyl having 1 to 5 halogen atoms, C₁₋₄-alkoxycarbonyl, benzyloxycarbonyl, C₁₋₄-alkoxy-C₁₋₄-alkylcarbonyl, -SO₂-C₁₋₄-alkyl, and -SO₂-C₁₋ ₄-halogenalkyl having 1 to 5 halogen atoms; R² is selected from the group consisting of hydrogen, halogen, cyano, -CHO, C₁₋₄-alkyl, C₂₋₄-alkenyl, C₂₋₄-alkynyl, C₃₋₆-cycloalkyl, C₁₋₄-halogenoalkyl having between 1 and 5 halogen atoms, C₁₋₄-alkoxy-C₁₋₄-alkyl, benzyl having between 1 and 5 halogen atoms, C₁₋₄-alkoxy, -NH₂,-NH (C -alquilo)-N (C -alquilo)-NH (C -cicloalquilo)-N (C₁₋₄-alkyl) (C₃₋₆-cycloalkyl),-NH (heterosexual of 4-7 members)-N (C₁₋₄ alkyl) (4-7 membered heterocycloalkyl),-NH (C -alcoxi)-N (C -alquil) (C -alcoxi)-NH-SO - (C -alquilo)-N (SO₂- [C₁₋₄-alkyl]) (C₁₋₄-alkyl),(C -alquil) -NH-C -alquilo-(C -alquil) -N-C -alquilo--S-C₁₋₄-alkyl, -S (O) -C₁₋₄-alkyl, -SO₂-C₁₋₄-alkyl, (C₁₋₄-alkoxyimino) -C₁₋₄-alkyl, and a monocyclic heterocycle selected from the 4- to 7-membered heterocycloalkyl group, the 5-membered heteroaryl having at least one nitrogen atom through which the heteroaryl ring connects to the rest of the molecule, and the 6-membered heteroaryl having at least one atom of nitrogen, each of which in R² is optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of hydrogen, halogen, cyano, nitro, -OH, oxo, thiono, C₁₋₄-alkyl,c. C8321c83318324 - halogen-1 to 5 halogen atoms, c8321;-NH (C -alquilo)-N (C -alquilo)-SC -alquilo -S (O) -C -alquilo -SO -C -alquilo -SC -hal genoalquilo -S (O) -C -hal genoalquilo y -SC -hal genoalquilo que tiene entre 1 y 5 tomos de hal geno -NH (C -alquilo)-N (C -alquilo)ciano carboxi carbamoilo alcoxicarbonilo -C (O) -NH (C -alquilo)-C (O) -N (C₁₋₄-alkyl) ₂,-C (O) -NH (C -cicloalquilo)C₁₋₄-alkoxy, -S-C₁₋₄-alkyl, -S (O) -C₁₋₄-alkyl, -SO₂-C₁₋₄-alkyl, or optionally substituted with a monocyclic heterocycle selected from the group of heterocycloalkyl of 4-7 membered or 5-membered heteroaryl having at least one nitrogen atom through which the heteroaryl ring connects to C₁₋₄-alkyl or C₃₋₆-cycloalkyl, each of which is optionally substituted by 1 , 2 or 3 substituents independently selected from the group consisting of hydrogen, halogen, cyano, nitro, -OH, oxo, thiono, C₁₋₄-alkyl, C₁₋₄-halogenalkyl having 1 to 5 halogen atoms ,c. C83321c833317a-8324a-alcoxi, c83321a-838331a-8324-halogenoalcoxic, including 1 to 5 halogen atoms, c833238331a-c833226c-cyclo-nhl-83222;-NH (C -alquilo)-N (C -alquilo)-S-C₁₋₄-alkyl, -S (O) -C₁₋₄alkyl, -SO₂-C₁₋₄-alkyl, -S-C₁₋₄-halogenalkyl, -S (O) -C₁₋₄-halogenalkyl and - SO₂-C₁₋₄-halogenalkyl having 1 to 5 halogen atoms; R³ is selected from the group consisting of hydrogen, halogen, C₁₋₄-alkyl, C₁₋₄-haloalkyl having 1 to 5 halogen atoms, and C₃₋₆-cycloalkyl; R⁴ is selected from the group consisting of hydrogen, halogen, C₁₋₄-alkyl, C₁₋₄-halogenalkyl having 1 to 5 halogen atoms, C₃₋₆-cycloalkyl, -S-C₁₋₄-alkyl, - S (O) -C₁₋₄-alkyl, and -SO₂-C₁₋₄-alkyl;R⁵ is selected from the group consisting of hydrogen, fluorine, and C₁₋₄-alkyl; R⁶ is selected from the group consisting of hydrogen, fluorine, and C₁₋₄-alkyl; R⁷ is selected from the group consisting of hydrogen and C₁₋₄-alkyl; Q is selected from the group consisting of 6 or 10-membered aryl and 5 to 10-membered heteroaryl, each of which may be optionally substituted with 1, 2, 3, 4 or 5 substituents; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture thereof.