biocompatible polymer gel composition, method of in situ formation of a protective coating on the biocompatible polymer gel composition, and uses of one or more polyanionic polymer and one or more of a polycationic polymer

摘要

Patent Summary: "In situ crosslinkable polymeric compositions and methods thereof". The present invention relates to a biocompatible polymeric composition for in situ crosslinking in a wound, which composition comprises 1) one or more polyanionic polymers, such as alginates or hyaluronates, capable of being cross-linked on the wound surface, and 2) a or more polycationic polymers, such as chitosan or deae-dextran, which assists in the solidification process as well as accelerates hemostasis without the need for pressure to be applied. The biocompatible polymeric composition may further comprise a cross-linking agent such as aqueous calcium chloride. The invention encompasses an initial polymeric composition, the crosslinked solidified matrix integrated with the wound site, including the methods of use, application and cross-linking of the composition.