carboxy terminal peptide-modified coagulation factor of chorionic gonadotropin (ctp), its method of production and use, as well as method for extending biological half-life, improving area under curve (auc), reducing dosing frequency or reducing the release rate of a coagulation factor and polynucleotide

摘要

A chorionic gonadotropin carboxy terminal peptide (CTP)-modified Factor IX, Factor VII or Factor VIIa coagulation factor having three CTPs attached to the carboxy terminus of said coagulation factor for use in reducing excessive bleeding or bruising or for use in maintaining hemostasis during surgery or during surgical interventions in a subject.