Long-acting chorionic gonadotropin carboxy terminal peptide-modified coagulation factors and related compositions and methods of use

摘要

A polypeptide consisting of a coagulation factor and one to five human chorionic gonadotropin carboxy terminal peptides (CTPs) attached to the carboxy terminus of said coagulation factor, wherein said coagulation factor is Factor VII or Factor VIIa, and wherein the sequence of said CTPs comprises the first 10 amino acids of SEQ ID NO: 4 (i.e., the amino acid sequence SSSSKAPPPS), and optionally, a signal peptide attached to the amino terminus of said coagulation factor. Pharmaceutical compositions comprising the polypeptides and medical uses thereof are also disclosed.