type 1 insulin-like growth factor receptor-specific antibodies and their use

摘要

The blood-brain barrier (bhe) prevents the transport of molecules larger than 500 daltons from the blood to the brain. receptor-mediated transcytosis (rmt) facilitates bhe transport of specific molecules that bind receptors on bhe-forming brain endothelial cells. an insulin-like growth factor receptor-binding antibody type 1 (igf1r) or fragment thereof is identified that transmigrates to bhe by rmt. The antibody or fragment is used to deliver a charge molecule across the bhe, wherein the charge molecule may be a therapeutic or detectable agent. The antibody is a camelid vhh prepared by immunizing a llama with a 933 amino acid igf1r polypeptide. Humanized forms of camelid vhh are also generated.