rodent, mouse, methods for rodent and mouse production and antagonist screening

摘要

non-human animals are provided which comprise a human or humanized il-4 and / or il-4r nucleic acid sequence. Non-human animals are described which comprise a replacement of the endogenous il-4 and / or il-4r gene with a human or whole il-4r gene and / or il-4r gene, and methods for producing and use of nonhuman animals. non-human animals comprising a human or humanized il-4 gene under the control of non-human il-4 regulatory elements, including non-human animals having a replacement of the non-human il-4 coding sequence with a sequence are also provided. coding for human il-4 at an endogenous non-human il-4 locus. non-human animals comprising a human or humanized il-4r gene under the control of non-human il-4r regulatory elements, including non-human animals having a replacement of the non-human il-4r coding sequence for a sequence are also provided. coding for human or humanized il-4r at an endogenous non-human il-4r locus. non-human animals are provided which comprise human or humanized il-4 and / or il-4r gene sequences, in which non-human animals are rodents, for example mice or rats.