trypecific binding molecule capable of immunospecific binding to three different epitopes, pharmaceutical composition, cancer treatment method, method of treating a disease associated with the presence of a pathogen, anti-ror1 antibody, or ror1 binding fragment, bispecific antibody fragment, bite or single chain antibody, and cancer treatment method

摘要

The present invention relates to trispecific binding molecules, which are multi-chain polypeptide molecules that have three binding domains and are therefore capable of mediating coordinated binding to three epitopes. the binding domains may be selected such that the trispecific binding molecules are capable of binding to any three different epitopes. These epitopes may be epitopes of the same antigen. or epitopes of two or three different antigens. In a preferred embodiment, one of these epitopes will be capable of binding to cd3, the second of these epitopes will be capable of binding to cd8, and the third of such epitopes will be capable of binding to an epitope of a disease associated antigen. The invention also provides an innovative ror1 binding antibody as well as derivatives thereof and uses for such compositions.