isolated monoclonal antibody or antigen-binding fragment thereof, isolated nucleic acid molecule, pharmaceutical composition, and method for lowering blood glucose levels or for treating a condition or disease.

摘要

The present invention provides glucagon binding antibodies and the method for their use. according to certain embodiments, the antibodies of the invention bind to high affinity human gcg. The antibodies of the invention may be completely human antibodies. The antibodies of the invention are useful for the treatment of various diseases or disorders characterized by elevated blood glucose levels as well as other gcg-related disorders.