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composition, oral solid dosage form, process for preparing porous effervescent granules, dual screw processor, and porous effervescent granules.
composition, oral solid dosage form, process for preparing porous effervescent granules, dual screw processor, and porous effervescent granules.
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机译:组合物,口服固体剂型,制备多孔泡腾颗粒的方法,双螺杆处理器和多孔泡腾颗粒。
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摘要
The present disclosure relates to effervescent compositions and methods for their preparation and use. In some embodiments, the described effervescent compositions are formed from an input mixture comprising an acid and a base by granulating the input mixture in a twin screw processor. The granules formed from the input mixture may be formed by an in situ granulating agent, which may be a portion of the acid that melts during granulation. in some embodiments, effervescent compositions may be made using a twin screw processor comprising an inlet zone for receiving an inlet mixture comprising an acid and a base; a granulation initiation zone for melting only a portion of the acid to serve as an in situ granulating agent; a granulation completion zone for granulating the input mixture; and an outlet for discharging the granules.
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