isolated, caninized and monoclonal antibodies or antigen binding fragment thereof, isolated nucleic acid, expression vector, host cell, isolated antigenic peptide, fusion protein, pharmaceutical composition, and method of enhancing the activity of an immune cell.

摘要

The present disclosure describes antibodies including canine canine pd-11 antibodies with specific properties. The document relates to canine pd-11 epitopes that bind to these antibodies, as well as to the canine pd-11 anti-canine antibodies that bind to these epitopes, and to the use of caninized pd-11 canine antibodies in the treatment of cancer in dogs.