isolated mammalian antibody or antigen-binding fragment thereof, caninized antibody or caninized antigen binding fragment thereof, caninized monoclonal antibody or antigen-binding fragment thereof, isolated nucleic acid, expression vector, host cell, peptide isolated, fusion protein, pharmaceutical composition, and method for decreasing the activity of an immune cell?

摘要

The present invention describes canine IL-4 alpha receptor blocking antibodies and antibodies that have specific sequences and a high binding affinity for the canine IL-4 α receptor. The present invention also describes the use of the antibodies of the present invention in the treatment of atopic dermatitis in dogs. The present invention further describes specific epitopes that bind to canine il-4 alpha receptor antibodies.