method for l-serine production using genetically engineered microorganisms deficient in serine degradation reaction series

摘要

The present invention generally relates to the microbiological industry, and specifically to the production of l-serine using genetically modified bacteria. The present invention provides genetically modified microorganisms, such as bacteria, wherein the expression of genes encoding enzymes involved in l-serine degradation is attenuated, such as by inactivation, which makes them particularly suitable for the production of l-serine at greater levels. Yield. The present invention also provides methods by which the microorganism, and more particularly a bacterium, can be made tolerant to higher concentrations of serine. The present invention also provides methods for producing 1-serine or 1-serine derivative using such genetically modified microorganisms.