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METHOD FOR THE PRODUCTION OF L-SERINE USING GENETICALLY ENGINEERED MICROORGANISMS DEFICIENT IN SERINE DEGRADATION PATHWAYS
METHOD FOR THE PRODUCTION OF L-SERINE USING GENETICALLY ENGINEERED MICROORGANISMS DEFICIENT IN SERINE DEGRADATION PATHWAYS
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机译:利用丝氨酸降解途径中的遗传工程微生物生产L-丝氨酸的方法
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摘要
The present invention generally relates to the microbiological industry, and specifically to the production of L-serine using genetically modified bacteria. The present invention provides genetically modified microorganisms, such as bacteria, wherein the expression of genes encoding for enzymes involved in the degradation of L-serine is attenuated, such as by inactivation, which makes them particularly suitable for the production of L-serine at higher yield. The present invention also provides means by which the microorganism, and more particularly a bacterium, can be made tolerant towards higher concentrations of serine. The present invention also provides methods for the production of L-serine or L-serine derivative using such genetically modified microorganisms.
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