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cancer and lymphoma treatment, prevention or inhibition methods, composition, kit, and therapy resistant cancer treatment method
cancer and lymphoma treatment, prevention or inhibition methods, composition, kit, and therapy resistant cancer treatment method
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机译:癌症和淋巴瘤的治疗,预防或抑制方法,组成,试剂盒和抗药性的癌症治疗方法
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摘要
The present application demonstrates that Salinosporamide A can be used to sensitize cancer cells to cancer therapy. Furthermore, the present application demonstrates that Salinosporamide A acts as a therapeutic agent to kill or inhibit cancer cells after sensitization of the cells by an antibody or other chemosensitizing reagents. The cancer cells can be either therapy-sensitive or therapy resistant. The present application further demonstrates that Salinosporamide A induces the expression of Raf kinase inhibitor protein (RKIP) and PTEN, tumor suppressor proteins, and inhibits the expression of YY1, a transcriptional regulator protein overexpressed in cancer cells and also inhibits the growth factor pleiotrophin (PTN).
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