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Process for the amidation of esters or acids C - terminal peptide substrates for the synthesis of peptides in solution phase
Process for the amidation of esters or acids C - terminal peptide substrates for the synthesis of peptides in solution phase
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机译:酯或酸酰胺化的方法C-末端肽底物用于溶液相合成肽
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摘要
The present invention relates to a process for the amidation of C-terminal esters or acids of peptide substrates in solution-phase synthesis of peptides, comprising amidating one or more peptide substrates comprising C-terminal esters or acids using the protease subtilisin in any suitable form in the presence of an ammonium salt derived from an acid having a pKa above 0. This process is useful in the production of protected or unprotected peptides.
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